In the tradition of UNDERWORLD and DISTRICT 9, all of Manhattan is quarantined when the Lupine virus spreads like wildfire, turning innocent civilians into ravenous wolves. Nothing short of a nuclear blast can stop the monstrous virus.
When Dakota tries to break off her toxic relationship with Axel, it starts transforming him into a monstrous creature. He gradually succumbs to the poison of the decaying relationship, becoming a creature with increased aggression, a touch that melts skin and worst of all, he's contagious.