Former special operative MacGruber is called back into action to take down his arch-enemy, Dieter Von Cunth, who's in possession of a nuclear warhead and bent on destroying Washington, D.C.
When Dakota tries to break off her toxic relationship with Axel, it starts transforming him into a monstrous creature. He gradually succumbs to the poison of the decaying relationship, becoming a creature with increased aggression, a touch that melts skin and worst of all, he's contagious.